Problem-Oriented Diagnosis

Drug-Induced Disorders

EILEEN G. HOLLAND, PHARM.D., and FRANK V. DEGRUY, M.D.

American Family Physician 56:7, 1 Nov 1997

Recent estimates suggest that each year more than 1 million patients are injured while in the hospital and approximately 180,000 die because of these injuries. Furthermore, drug-related morbidity and mortality are common and are estimated to cost more than $136 billion a year. The most common type of drug-induced disorder is dose-dependent and predictable. Many adverse drug events occur as a result of drug-drug, drug-disease or drug-food interactions and, therefore, are preventable. Clinicians’ awareness of the agents that commonly cause drug-induced disorders and recognition of compromised organ function can significantly decrease the likelihood that an adverse event will occur. Patient assessment should include a thorough medication history, including an analysis of all prescribed and over-the-counter medications, vitamins, herbs and “health-food” products to identify drug-induced problems and potentially reversible conditions. An increased awareness among clinicians of drug-induced disorders should maximize their recognition and minimize their incidence.

A new supplement to The Scientist is basic reading for anyone interested in affecting cancer with frequency devices. In particular, if you do not adopt many of the strategies outlined in these articles you will not be successful.

The Scientist

Volume 17 | Supplement 2 | September 22, 2003

Editorial | New Frontiers in Cancer Research

Preventing Cancer

The unraveling of the genetic roots of cancer highlights more controllable risk factors

Aberrant Signaling

Overlapping and interacting, the pathways that control the cell cycle can resemble a plate of spaghetti, and when dysfunctional, can lead to cancer

Dysfunctional Signaling Pathways in Cancer

The Ubiquitin System in Cancer

Is protein degradation or preservation a key to saving patients?

DNA Expression Profiling: A New Lens on Cancer

The seeds of spread may be sown early

Setting the Stage for Cancer

Diagnosing Cancer: A Genomics and Proteomics Approach

Detecting tumors earlier and integrating diagnostics more closely with therapeutic decisions should improve survival

Birth of an Epithelial Cancer

The Current Status of Cancer Treatment

Targeted therapy takes hold, but mysteries of tumor susceptibility and resistance to drugs persist

Into the Future

Personalized medicine will ride a tide of precise new biomarkers and drugs

Frequency of Cancers Around the World

The 21st Century War on Cancer

Researchers look for more coordination among government, organizations, and industry

The publicity campaign for flu shots was launched today. Before you sign up for one you should review information at the National Vaccine Information Center. A recent Institute of Medicine studied questioned the impact of vaccinations on childhood immune systems. Also the vaccines have mercury, aluminum, and ethylene glycol in them as preservatives.

The flu can kill people of all ages and new research shows that some children, in addition to older people, have died from the flu in recent years. Therefore, you must protect yourself. Doing nothing is not a good option.

Homeopaths have objected to vaccinations for decades because of the negative impact on the immune system. Viral infections can often be treated effectively with homeopathy and Oscillicoccinum is the biggest selling product of Boiron, probably the largest medical company in the world supplying homeopathic remedies. The reason is that it works extremely well in preventing or ameliorating the flu when taken at first sign of infection.

Furthermore, new immune enhancing nutritional supplements are potentially better than a vaccine at protecting against a flu. The flu shot this year is based on the best guess of the viral strain. About 50% of the time, that guess is wrong. Even when it is right, a substantial number of people getting the flu shot will still get the flu. Clinical studies show that Transfer Factor Plus enhances the power of the immune system substantially better that other immune supplements and it routinely protects me from the flu, colds, and other infections on my frequent airline travels.

The combination of Oscillicoccinum and an immune enhancing supplement suppressed a flu epidemic in my company in a single afternoon a couple of years ago. This was after everyone was infected in a small confined office of about 50 people. I wouldn’t be without it and it is my preventive measure of choice.

Consult your physician about this because you need to do something and you may jointly conclude that the flu shot is the best choice in your case.

One of the main themes of this web site is that over 50% of any disease is unnecessary. Simple nutritional strategies can prevent them in most cases. Here, we see that 60% of Alzheimer’s disease can be avoided by eating fish once a week. Better yet, take pharmaceutical grade fish oil, avoid toxic chemicals, and get a cornucopeia of positive effects on the heart, brain, and general physical performance.

Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease.

Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Wilson RS, Aggarwal N, Schneider J.

Arch Neurol. 2003 Jul;60(7):923-4

BACKGROUND: Dietary n-3 polyunsaturated fatty acids improve brain functioning in animal studies, but there is limited study of whether this type of fat protects against Alzheimer disease.

OBJECTIVE: To examine whether fish consumption and intake of different types of n-3 fatty acids protect against Alzheimer disease.

DESIGN: Prospective study conducted from 1993 through 2000, of a stratified random sample from a geographically defined community. Participants were followed up for an average of 3.9 years for the development of Alzheimer disease.

PATIENTS: A total of 815 residents, aged 65 to 94 years, who were initially unaffected by Alzheimer disease and completed a dietary questionnaire on average 2.3 years before clinical evaluation of incident disease.

MAIN OUTCOME MEASURES: Incident Alzheimer disease diagnosed in a structured neurologic examination by means of standardized criteria.

RESULTS: A total of 131 sample participants developed Alzheimer disease. Participants who consumed fish once per week or more had 60% less risk of Alzheimer disease compared with those who rarely or never ate fish (relative risk, 0.4; 95% confidence interval, 0.2-0.9) in a model adjusted for age and other risk factors. Total intake of n-3 polyunsaturated fatty acids was associated with reduced risk of Alzheimer disease, as was intake of docosahexaenoic acid (22:6n-3). Eicosapentaenoic acid (20:5n-3) was not associated with Alzheimer disease. The associations remained unchanged with additional adjustment for intakes of other dietary fats and of vitamin E and for cardiovascular conditions.

CONCLUSION: Dietary intake of n-3 fatty acids and weekly consumption of fish may reduce the risk of incident Alzheimer disease.

Medical technologises should check out TRIZ, a Russian acronym for “theory of inventive problem-solving.” The picture above represents a problem in thermodynamics where a solution is looked for in mechanical effects. Just as the drunk looks for lost keys under the street lamp, the expert looks for the solution in his or her area of expertise, when the real breakthrough technology might be found elsewhere.

Substitute radiation therapy for thermo-dynamics, pharmaceuticals for chemical effects, and surgery for mechanical effects and you have a picture of the field of medicine. Major future breakthroughs will occur in electromagnetic devices and psychologic inertia will prevent current players from capturing the benefits of new technologies.

The most important supplement to take along with your vitamins is molecular distilled fish oil. It has huge benefits. I get mine from Sears Labs.

The role of fish oils in the treatment of rheumatoid arthritis

Cleland LG, James MJ, Proudman SM.

Drugs. 2003;63(9):845-53

Fish oils are a rich source of omega-3 long chain polyunsaturated fatty acids (n-3 LC PUFA). The specific fatty acids, eicosapentaenoic acid and docosahexaenoic acid, are homologues of the n-6 fatty acid, arachidonic acid (AA). This chemistry provides for antagonism by n-3 LC PUFA of AA metabolism to pro-inflammatory and pro-thrombotic n-6 eicosanoids, as well as production of less active n-3 eicosanoids. In addition, n-3 LC PUFA can suppress production of pro-inflammatory cytokines and cartilage degradative enzymes.In accordance with the biochemical effects, beneficial anti-inflammatory effects of dietary fish oils have been demonstrated in randomised, double-blind, placebo-controlled trials in rheumatoid arthritis (RA). Also, fish oils have protective clinical effects in occlusive cardiovascular disease, for which patients with RA are at increased risk. Implementation of the clinical use of anti-inflammatory fish oil doses has been poor. Since fish oils do not provide industry with the opportunities for substantial profit associated with patented prescription items, they have not received the marketing inputs that underpin the adoption of usual pharmacotherapies. Accordingly, many prescribers remain ignorant of their biochemistry, therapeutic effects, formulations, principles of application and complementary dietary modifications. Evidence is presented that increased uptake of this approach can be achieved using bulk fish oils. This approach has been used with good compliance in RA patients. In addition, an index of n-3 nutrition can be used to provide helpful feedback messages to patients and to monitor the attainment of target levels.Collectively, these issues highlight the challenges in advancing the use of fish oil amid the complexities of modern management of RA, with its emphasis on combination chemotherapy applied early.

The Scientist :: Dark chocolate is healthier by Tudor Toma

Milk interferes with the absorption of antioxidants from dark chocolate and negates its benefits.

The high antioxidant capacity of dietary flavonoids found in cocoa and chocolate may have beneficial effects in the treatment of degenerative diseases such as atherosclerosis, but the link between dietary habits and the protective effects of flavonoid-rich foods has been unclear. In a Brief Communication in the August 28 Nature, Mauro Serafini and colleagues from National Institute for Food and Nutrition Research show that milk may interfere with the absorption of antioxidants from chocolate in vivo and may therefore negate the potential health benefits that can be derived from eating moderate amounts of dark chocolate (Nature, 424:1013, August 28, 2003).

The French not only have fewer heart attacks, they live longer. Nature, one of the leading scientific journals, just published a paper showing certain substances extend the live of yeast. These substances are seen in cells of humans who use fasting to extend life, the only known effective means for definitive human life extension.

So your glass of red wine may be better than you think! Watch out. The French have a high rate of liver disease because of drinking too much red wine.

A note on the FSCAN list today asked about frequencies for eye floaters. A pointer to an Italian web site referenced the following parasites:

1 – Dirofilaria spp. (a)

2 – Onchocerca volvulus (a)

3 – Toxocara canis (b)

Taking a look at the first one, the image above is a thumbprint of a eye with a Dirofilaria spp. infection provided on the web by Drs. Biglino and Casabianca of the Asti General Hospital Department of Infectious Diseases. This is a parasite with a four stage life cycle. Each stage has its own frequency:

476656 344535 256235 155764

The bandwidth of this organism is about 16hz, i.e. you must treat 16hz above and below this frequencies. Each frequency will need treatment for about 30 minutes with the pads near the eyes.

For EMEM users, lower octaves must be used to get into the Rife range. The preferred driver device is an F100 and the program would be as follows:

dwell 1800

duty 50

pulse 64 75

converge 4 1

1861.94

1345.84

1001.70

612.40

I tested myself for this parasite and sure enough, tested positive. Hmm, where would I have picked this up? Tested one of my cats who has a chronic eye infection and sure enough she has it. The other cat and other family members don’t have it so it looks like you must be susceptible to pick it up.

Click here for the FSCAN file I used to treat myself. It is a good idea to plate zap the optic nerve for any eye infection. I use a microscopic slide from Carolina (Human Optic Nerve c.s. 31-3828 (H6880)). Colors got a little brighter and vision a little sharper after zapping these critters.

The neat thing about eye floaters is that you can often see them floating in your eye, particularly if you stare at a plain light colored wall. When you hit them with the right frequency they change from a sharp outline and disperse into a black mist and disappear. I use to fly fighter aircraft and if you hit a target with a missile it looked very much the same. A sharp pointed object turns into a cloud of black smoke with fragments flying leaving a smokey mist that gradually dissipates.

Frequency lists for specific organisms provide a starting point for investigation. However, the exact frequency of the organism that you are infected with may vary.

There are organisms that are fairly stable. For example, the corona virus frequency for SARS of 33566 was identified in multiple people and successful eliminated, although many repeated frequency applications were required, along with a whole set of other frequencies for associated organisms.

It was clear within a few days that there were strains of this corona virus as low as 33560 that needed to be hit to knock it out. Then two weeks later a significantly different new strain appeared at a lower frequency. This is suggestive of an altered genetic structure.

None of these organisms could be knocked out without an exact frequency within 1HZ. And the evolutionary cycle time of many organisms we are dealing with is weeks or months, not years. Have you read Paul Ewald’s books on evolutionary biology?

The SV40 virus, for example, has two different forms which you can see under an electron microscope. They have two different frequencies. They seem to be fairly stable across individuals, but you must have both frequencies and you must be able to deal with strains that appear at slightly different frequencies.

This is typical for dealing with all organisms. As soon as you knock out one strain, another proliferates. You must adjust to target a new frequency to nail the new strain.

Again, you must:

1. Be able to identify exact frequencies in real time (for all organisms, strains, and life cycle stages). Most chronic conditions result from the interplay of several organisms. You must nail them all.

2. Have a biological model that matches what you are dealing with. (How many life cycle stages does that parasite have? Is it a pleomorphic organism that has the same DNA but different forms? Do you have the right frequency for all stages or forms? Is candida or some nasty bacteria interacting with this organism to suppress the immune system? When you kill one or more organisms, what is released? Have you eliminated all sources of reinfection from you external environment and your internal environment? And so forth …

3. Develop a clinical protocol to fit the model. (What do you treat first? When do you treat it? How long? With what? Does the person need Transfer Factor to enhance their immune system for frequencies to be effective? What organ systems does the organism reside in primarily? What organs does it run to when you hit it? Is the device you are using penetration to the right organ systems? Many organisms will never be eliminated from the body without plate zapping. Candida will never be eliminated without zapping all octaves of a specific strain.

Virtually all reports of lack of success are related to these three issues. Herx reactions are also the result of not understanding what is released when you kill an organism and being unable to target the released organisms, unable to identify what organs are affected, and unable to transmit the right frequency for the right time in sufficient power to the right target organ.