Aspartame induces lymphomas and leukaemias in rats
Morando Soffritti, Fiorella Belpoggi, Davide Degli Esposti, Luca Lambertini
Eur. J. Oncol., 10 (2), 00-00, 2005
Aspartame, a widely used artificial sweetener, was administered with feed to male and female Sprague-Dawley rats (100-150/sex/group), 8 weeks-old at the start of the experiment, at concentrations of 100,000; 50,000; 10,000; 2,000; 400; 80 and 0 ppm. Treatment lasted until spontaneous death of the animals. In this report we present the first results showing that aspartame, in our experimental conditions, causes a statistically significant, dose-related increase in lymphomas and leukaemias in females. No statistically significant increase in malignant brain tumours was observed
among animals from the treated groups as compared to controls.